Top-line clinical results from US study with lead candidate IdeS to be presented at the American Transplant Congress
The abstract, titled “Experience with The Bacterial Enzyme IdeS (IgG Endopeptidase) for Desensitization of Highly-HLA Sensitized (HS) Kidney Allograft Recipients“ concludes that: 1. IdeS completely eliminates donor specific antibodies in HLA incompatible patients. 2. IdeS is generally well tolerated with acceptable adverse events and 3. IdeS may provide a more rapid and durable method to desensitize HLA sensitized patients, offering them the benefits of life-saving transplantation. IdeS, IgG degrading enzyme of Streptococcus pyogenes, is an enzyme that depletes IgG antibodies fast and effectively. Hansa Medical is developing IdeS as a proprietary treatment to enable kidney transplantation in sensitized patients. In the US study, 15 highly sensitized patients with mean cPRA 95% received IdeS 4-6 hours prior to incompatible kidney transplantation. The IdeS treatment resulted in total IgG and HLA antibody elimination. Fourteen of 15 patients were successfully transplanted without discernible adverse events. Antibody mediated rejection episodes occurred in four patients and all four responded to anti-rejection treatment. One graft loss occurred due to non-HLA IgM and IgA antibodies. A comparison of the levels of donor specific antibodies before IdeS treatment and one month after IdeS treatment shows a significant reduction.
The abstract supports the company’s conviction that IdeS could become the first therapy to enable highly HLA sensitized kidney disease patients to be transplanted. HLA sensitization impacts approximately 30% of patients with kidney disease and is a major barrier to kidney transplantation.
The title, timing and location of the presentations are as follows:
|Authors:||S Jordan, MD1, J Choi, PharmD1, C Kjellman, PhD2, L Winstedt, PhD2, X Zhang, PhD4, S Louie, MPh1, A Kang, BS1, M Haas, MD, PhD3 and A Vo, PharmD1. 1Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2Hansa Medical, Lund, Sweden; 3Dept of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, United States and 4HLA, Cedars-Sinai Medical Center, Los Angeles, CA, United States.|
|Title:||Experience with The Bacterial Enzyme IdeS (IgG Endopeptidase) for Desensitization of Highly HLA Sensitized (HS) Kidney Allograft Recipients|
|Day/Date:||30 April 2017|
|Session:||Concurrent Session: Novel Immunosupression – DSA Monitoring|
|Session Type:||Oral presentations|
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